Author: Board Members

🔊 Listen
We heard from many of you after the last blog when we compared Dry Eye to having a 125-foot orange in your mouth. We guessed that nobody would tell you a sip of water would help wash it down.

That got us thinking. Could there be other things you’d never hear again if you had a 125-foot orange in your mouth?

Absolutely!

In fact, it took literally no time to come up with more – 10 things you’d never hear again from your families, your friends, and your doctors if you had a 125-foot orange in your mouth.

Here they are, in no particular order.

1. At least you don’t have cancer

The word “cancer” really gets everyone going. Yes, in lots of cases it’s a horrible disease that can be fatal. But there are lots of different kinds of cancer, and some are very treatable. Regardless, can you imagine anyone saying “at least you don’t have cancer” if they saw you walking down the street with a 125-foot orange in your mouth? We couldn’t either.

2. You’ll learn to live with it

We can’t joke around about this when we know people who have committed suicide because of the pain in the eyes. Others become disabled, unable to work, unable to perform simple daily tasks. So no, some of us will never “learn to live with it.” And like some cancers, Dry Eye can cause death.

But that orange, no one is ever going to say you’ll learn to live with something that big in your mouth. Heck, the Charlie Brown balloon in the Macy’s Thanksgiving Day Parade is just 53 feet long, 31 feet wide, and 46 feet tall.

Your orange is way bigger than that.

3. It’s all in your head

No-o-o-o-o-o-o, it’s not all in our heads. It’s all in our eyes.

And in the case of the 125-foot orange, it’s all in our mouths. Enough said!

4. But your face looks good

As if the only time your eyes might feel bad is when they’re red or swollen or something other than clear and bright. Macular degeneration anyone? But with a 125-foot orange in your mouth we’re pretty sure there’s going to be some distortion to your face and nobody’s going to think your face looks good. Nobody.

5. You can’t possibly have a 125-pound orange in your mouth

The worst thing is when nobody believes what you’re feeling in your eyes.

But the orange – there it is – all 125 juicy feet. Now, doc, please DO SOMETHING!

6. I don’t know what it is so I’ll call it neuropathy

Neuropathy seems to be the new catchall “disease” diagnosed by a variety of specialists these days. Ocular neuropathy is extremely rare, yet there’s a trend these days to attribute chronic Dry Eye symptoms to neuropathy. But is it neuropathy or is it, in fact, a case of inadequate diagnosis or misdiagnosis? Because in the eyes – with that high concentration of nerves – something exceedingly small that can’t be easily detected – can still feel significant.

But, if you had a 125-foot orange in your mouth, chances are the doctor wouldn’t call it neuropathy. Instead, he’d say something useful like, “Your problem is that you have a 125-foot orange in your mouth.”

7. I don’t see anything in there

The next word out of the doctor’s mouth will be “neuropathy.” (See number 6 above). But there really is an underlying issue here.

Let’s first take a short quiz.

Question: What are the three most important things in real estate?

Answer: Location, location, location, in that order.

Question: What are the three most important things in engineering?

Answer: Drainage, drainage, drainage, in that order.

Question: What are the three most important things in medicine?

Answer: Diagnosis, diagnosis, diagnosis, in that order.

Unsurprisingly, that 125-foot orange makes diagnosis real easy.

8. Your tests results are all negative

See number 7 above.

Signs (exam and test results) and symptoms (what you feel) often don’t coincide for Dry Eye patients.

But that 125-foot orange probably wouldn’t even warrant any medical tests. It’s just that obvious.

9. You might have symptoms, but there are no signs of disease

Really doctor? Maybe you need to sharpen your diagnostic skills, because Dry Eye patients can feel extreme pain and discomfort, even when there are no signs of disease.

But who could miss a 125-foot orange in anyone’s mouth. That’s unmistakable, although it would be pretty shocking.

10. Don’t they have drops for that?

No, they don’t have drops for what many of us have. And they don’t have drops, or prescribe drinks of water, to get 125-foot oranges out of people’s mouths either.

So next time someone says something to you about how good your eyes look, or that what you’re feeling is all in your head, or that you’re lucky you don’t have cancer, or whatever other nonsense you here all the time, you might try telling them about the 125-foot orange. Maybe it will change their mind.

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🔊 Listen
Are you a patient Dry Eye Patient? In two words, probably not. In fact, you’re probably impatient and frustrated.

You’re sick of well-meaning people saying “just use some eye drops.” You’re tired of thinking about your eyes. You can’t believe how much money you’ve spent on them. You’re confused about the conflicting advice you get from doctors. When you let yourself look back at the life you once led, you wonder if you’ll ever get any of it back.

Take heart, you will.

If you’re patient, chances are – with the help of your doctor(s) – you will eventually figure out what’s going on and what needs to be done about it.

But it takes perseverance and patience. And that’s just not something most Dry Eye patients have. Who would when it feels like there’s a knife, or a log, or a boulder lodged in their eye?

The 125-Foot Orange

Remember the first time you woke up in the morning feeling like there was a knife in your eye? Did you panic? Did you want something done about it NOW!?!?!?

Sure you did. Here’s why. The eye has 300 – 600 times more nerves than any other part of the body. So something that’s small, like an eyelash, can feel 600 times bigger.

Let’s put that in perspective.

An average orange is about 2.5 inches in diameter. If it were 600 times bigger it would be 125 feet in diameter. That’s an enormous difference. You’d notice if you had a 125-foot orange in your mouth! And you’d probably want somebody to take it out RIGHT AWAY!

All of your friends would notice too, and nobody would suggest sipping a little water to make it go down easier. They’d be right there by your side, calling 911, pulling out their juicers, and FREAKING OUT!

The Impatient Dry Eye Patient

When panic sets in we become irrational. Our thinking becomes clouded. We lose patience and get angry, lashing out at our doctors, at our friends, our families, and even at other Dry Eye patients. We thrash around as if we’re drowning. But the thrashing just makes things worse.

We don’t believe our doctors. How can we when they tell us different things? We wonder if we’ve been diagnosed properly. Will the treatment be effective? Will we ever, ever get on with life?

It’s an ongoing battle. Actually, it’s more like a war.

On Your Way to Healing

Like with any war, you need to know your enemy and its allies (all of the co-morbidities that complicate things), inside and out. How they behave. How they respond. What they’re going to do next.

Then there’s treatment. Remember that patience and steadfastness are on your side, even when it feels like there’s a log in your eye.

That’s when it’s especially helpful to stop, breathe, reflect, and remember that you’re on your way to healing. And healing, like all good things, takes time.

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🔊 Listen

It may have started with some dryness or or feeling like there’s something in your eye. You’d seen countless commercials for eye drops that promised to help. When you got to the drug store you were overwhelmed. Who knew there were so many different drops? And the price, especially for the preservative-free versions, probably gave you sticker shock. So you opted for drops that didn’t seem too expensive, even if the bottle turned out to be ant-sized.

At first maybe your eyes felt better. But then, after a while, they felt worse. Pain. Burning. Redness. More pain. More burning. Feeling like someone plunged a knife in your eye, or worse. There can be worse?!?!?!?

What the heck was going on? You tried researching online, but reading was becoming more and more painful.

Finally, you saw a doctor, maybe an optometrist. Maybe an ophthalmologist. Maybe even more than one.

Treating Dry Eye is Like Baking a Cake

What did they prescribe?

Lubricating eye drops. Warm compresses. Lid wipes. And, talk about sticker shock, Restasis. Maybe you started taking Omega 3’s.

Come back in 6 or 8 weeks, they said.

Maybe after a while you felt better. If you did, you were lucky. The treatments worked. You could get on with life.

But maybe you didn’t feel better. Why? Because treating Dry Eye is a lot like baking a cake. Here are four reasons why.

REASON #1 – Lots of Recipes

They all have some kind of flour and some kind of sugar, but there are literally countless recipes for cake. Chocolate. Vanilla. Strawberry shortcake. Angel food. Devil’s food. Cupcakes anyone? Boston creme pie. It’s not really pie, is it? What about frosting or drizzle? Is one tier ever really enough? Bundt. Pound. Pineapple upside down cake. Pineapple upside down CUPcake. Now we’re talking! What about a flourless chocolate cake?

There’s literally the same endless variety with Dry Eye. Each and every one of us is pretty much the same. We’re all human. We all have DNA. But at the same time we’re all completely and utterly unique. So if your doctor is treating you as if you were a statistic, or exactly like the patient who came before you, you might not feel better. It’s one of the most frustrating things about Dry Eye. But don’t despair. Just like with baking a cake, eventually you’ll figure out which recipe for treatment is right for you.

REASON #2 – You Really Do Need a Recipe

You could try throwing some flour and sugar into a bowl, adding some butter, maybe some eggs. Mix them up. Pour into a cake pan and put it in the oven. But at what temperature and for how long? If you take this approach – without a recipe – chances are your cake will turn out yucky. On the other hand – start with a recipe – and you’ll improve your chances of ending up with something luscious that might even be beautiful.

Why is this like Dry Eye? Because before you start throwing treatments at your eyes, you first need to know exactly what you’re treating. Do you have meibomian gland dysfunction? Restasis probably won’t help much. Do you have aqueous deficiency? Lid wipes, not so much. Demodex mites? Skip the serum tears. Foreign body sensation? It’s anybody’s guess.

One of the things Dry Eye sufferers sometimes try is the shot gun approach. They throw any and every treatment at their eyes in the hopes that something will work. Maybe some will. Others won’t. The danger with this is approach is that some conditions could go undiagnosed and untreated. And if something helps, it’s anyone’s guess what does and what doesn’t. So you won’t know which treatment to stop or which one to keep doing.

Maybe you do need lubricating drops, warm compresses, lip wipes and Restasis. But maybe you need more. With a good and comprehensive diagnosis, just like with a good cake recipe, you’ll find out what specific conditions you have. Your treatments will target them and you’ll have a much better chance of a good outcome.

REASON #3 – The Better the Ingredients the Better the Results

Even if you have a good recipe your cake will only be as good as the ingredients its made of. If you use rancid butter or rotten eggs your cake will be horrible. But baked with good quality butter, fresh eggs, and other quality ingredients, your cake stands a good chance of being scrumptious.

It’s the same with Dry Eye. If you’re using lubricating drops regularly, avoid the ones with preservatives. If you apply warm compresses, only let the cleanest materials touch your eyes. And wash your hands. Don’t touch your eyes for any reason unless you’ve just washed your hands. Rest your eyes often and get a good night’s sleep. In other words, do everything you can to give your eyes a chance to feel better.

And then don’t stop doing it!

REASON #4 – The Better the Baker, The Better the Cake

Yes, just about anyone can make a cake from a mix that’s moist and delicious. But if you want something truly spectacular you’ll turn to an experienced baker who really knows her craft.

It’s the same with doctors. Most can treat mild forms of Dry Eye. But if your symptoms just aren’t going away, you may need to look for a Dry Eye specialist, typically an ophthalmologist who specializes in Cornea and External Diseases. These doctors will usually have the most training and the largest set of tools (just like professional bakers in professional kitchens), to treat all of the various co-morbidities contributing to your symptoms.

Whatever you do, whichever recipe you choose, don’t give up. There are lots and lots of cake recipes out there and lots and lots of treatments for your condition. That means there’s always hope!

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🔊 Listen
If you’re a Restasis user, you’ll want to watch the Allergan and Imprimis battle.

Before we look into that, you’ll be happy to learn Imprimis announced it will soon offer a lower-cost alternative.

Allergan released a multi-dose version of Restasis a few months ago. But it charged the same high price as the single-dose vial version.

Patients have been storing what was left in the vials for later use. By squeezing out a few more drops from those single-use vials they could save some money. But a multi-dose version could end that practice, improving Restasis sales.

But what’s good for Allergan’s bottom line still left patients with hundreds of dollars a month in out-of-pocket expenses.

Allergan and Imprimis Battle

Enter Imprimis, a California-based compounding pharmacy.

Imprimis announced on October 19, 2017 that it will fill initial prescriptions of a generic version of Restasis (cyclosporine) for just 99 cents. Refills will start at $79 a month. Cyclosporine, an immunosuppressant, is the active ingredient in Restasis.

Imprimis’ is even working on a spin-off. Surface Pharmaceuticals will seek FDA approval for drugs for Dry Eye, blepharitis and other ocular surface diseases.

But the announcement prompted Allergan to file a lawsuit against Imprimis citing patent protection.

Congress Takes Notice

The patent protection saga is in itself noteworthy. Allergan transferred the Restasis patent to the Saint Regis Mohawk tribe, a Native American tribe in upstate New York. This move would quash any patent challenges filed by competing drugmakers. By default, that would extend patent protection.

According to Bloomberg.com:

The pact, which will entitle the upstate New York tribe to a one-time $13.75 million payment and $15 million a year in royalties, could open up a new way for drugmakers to head off challenges to patents backing billions of dollars a year in sales.

Technology companies have used similar moves in the past.

Getting the Congressional Attention

However, Allergan’s move didn’t go unnoticed. This one even got the attention of Congress. On October 3, 2017 members of the House Committee on Oversight and Government Reform sent a letter to Allergan’s CEO Brent Saunders. The letter reads:

The sovereign status of Native American tribes adds time and complexity to contesting the status of the patents in question, because tribes may be immune from the legal claims generic drug makers use to challenge patents and bring less costly drugs to market more quickly.

The implications of Allergan’s patent transfer raise questions for Congress as the exchange may impair competition across the pharmaceutical industry and ultimately dissuade companies from pursuing less-costly generic alternatives to brand drugs.

The letter goes on to ask Allergan for detailed documentation regarding the transfer of the patent. The deadline for submitting the information was October 17.

Allergan’s battles with Congress started a day earlier. On October 2, Sen. Clair McCaskill (D-Missouri) wrote to the Pharmaceutical Research and Manufacturers of America, asking the group to investigate if Allergan’s action with the tribe was “consistent with the mission” of the trade organization.

I ask that PhRMA review whether actions to block patent challenges through claims of tribal sovereign immunity align with PhRMA efforts to promote innovation and discourage predatory pricing practices and anticompetitive conduct.

A few days later she introduce legislation to do away with the sovereign immunity defense when challenges are made to the validity of U.S. patents before the U.S. Patent and Trademark Office.

But Does It Work?

The widely-advertised treatment for Dry Eye has had issues from the start. For example, in clinical trials it was only effective in about 10-15% of patients. According to the product information sheet distributed with each prescription:

RESTASIS demonstrated statistically significant increases in Schirmer wetting of 10 mm versus vehicle at six months in patients whose tear production was presumed to be suppressed due to ocular inflammation. This effect was seen in approximately 15% of RESTASIS ophthalmic emulsion-treated patients versus approximately 5% of vehicle-treated patients.

So if you do the math, Restasis helped about 10-15% of trial participants. Even so, it reached the FDA efficacy threshold of 10%.

Since it’s prescribed to lots of Dry Eye patients, it’s no wonder Allergan is protecting its patent. Who wouldn’t if they stood to lose some $1.5 billion in revenue, the amount Restasis brought in last year.

References

Congress probes Allergan’s patent deal with Native American tribe
Helio Ocular Surgery News
October 6, 2017
View the full report

Imprimis to offer low-cost alternative to Restasis
October 19, 2017
Helio Ocular Surgery News
View the full report

Letter to Brenton L. Saunders
Committee on Oversight and Government Reform, United Stated House of Representatives
October 3, 2017
View the full report

A Native American tribe, a drugmaker and an unusual patent plan
C Koons, S. Decker
Bloomberg.com
September 8, 2017

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🔊 Listen
If you’re a patient wondering why your Dry Eye symptoms aren’t getting better, you might ask yourself these three questions.

1. Are you describing your symptoms accurately?

There’s not much a doctor can do for you if all you say is your left eye doesn’t feel good. Your doctor will have to ask more questions before she knows what’s really going on. But if you’re specific from the start about what you’re feeling, e.g.: my left eye burns all over and I see bubbles in the tear film, your doctor might still have to ask a few questions (and even examine you), but at least you’ll be one step closer to an accurate diagnosis.

It helps the doctor if you’re clear, concise, and descriptive. Take a few moments, focus on what you’re eyes are feeling, and find the words that accurately describe your symptoms.

Plus, be sure to tell your doctor right away if you experience a new symptom. Let her know if treatment isn’t giving you the expected relief. You doctor can’t help you if she doesn’t know what’s going on.

2. Is your doctor really listening to you?

As long as you’re very clear about your symptoms and reporting them in a timely manner, your doctor should listen and not be dismissive. Your doctor probably knows something you don’t. But a doctor who doesn’t really listen to what you’re saying, or a doctor who’s rude or dismissive, just might not be the right one for you.

Sometimes it’s not just doctors who don’t listen. Sometimes it’s the organizations that represents doctors. We came across this last year when we reached out to the Tear Film and Ocular Surface Society (TFOS). As a patient organization we had hoped to provide the patient perspective to the upcoming Dry Eye Workshop II. Unfortunately, the organization’s leadership declined our participation. So instead we wrote a letter.

Not A Dry Eye Foundation’s Letter to DEWS II

We sent the letter to the over 100 DEWS II participants. None of the participants wrote back. (So much for welcoming patient input). Maybe they’re just not aware of the importance of patient participation in healthcare. Here’s an example. The National Academy of Medicine (NAM), will be holding a meeting on July 17, 2017, in Washington D.C. to improve diagnosis in health care. One break-out group focusing on Patient-Centered Health Care, Education and Policy to Improve Diagnosis, will be asked these questions:

How can patient advocates improve the emphasis on patient-centered policies related to diagnosis in clinician practices, hospitals, and within the larger policy arena?

How can patient involvement in the diagnostic process be encouraged at all levels, including in the creation and implementation of policy, in addition to clinician-patient interactions?

Are you/Is your organization considering opportunities to better involve patients and families in promoting and improving patient-centeredness in diagnosis?

These are just a few sample questions, but do you notice the focus on patient input and patient participation?

Needless to say, we’re looking forward to reviewing the DEWS II reports when they come out later this year. We may even write them another letter.

3. Could it be the drops you’re using?

You’ve probably heard the saying, the treatment is worse than the disease. It’s true for eye treatments too.

It’s possible to develop allergies, or sensitivities, to the medicine that’s supposed to make you feel better. Preservatives and other compounds in drops and ointments can cause irritation. So if your symptoms persist, and you’re using a drop or ointment, or any other topical treatment, let your doctor know. Ask if the medicine could be the cause. Your doctor might suggest a different medication or tell you to stop the one you’re using altogether.

There are countless reasons why Dry Eye patients suffer with chronic symptoms or why new symptoms crop up. Asking yourself these three questions can help you embark on your journey to healing faster.

 Please note, the Dry Eye blog will be on vacation for the rest of the summer. Be sure to subscribe to our blog to hear from us as soon as we get back.

Reference

Improving Diagnosis in Health Care: Implementation Workshop
Quality Chasm Series
Briefing Book
July 17, 2017
The National Academy of Sciences
Lecture Room
2101 Constitution Avenue NW
Washington D.C. 20418

 

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🔊 Listen

Living with Dry Eye isn’t easy. Eventually you figure out what you can do to avoid additional pain, but it can take a lot of trial and error. I hope my 50 tips for living with Dry Eye will help you avoid, or manage, the pain of Dry Eye.

Read Susie Brockman’s amazing Story of Hope

Dry and Windy Places

1. Turn off all ceiling fans. The air movement will dry eyes out even more.

2. Turn off overheard air vents on planes as soon as you board.

3. Close air vents in cars and bedrooms.

4. Keep windows rolled up in the car.

5. When flying, use nighttime gel and drops. Drink lots of water. Lower the window shade on your row.

6. If possible, vacation in humid environments. Climates that are dry can make the eyes much, much worse.

7. Avoid windy conditions and places whenever possible e.g. make sure the vent in a restaurant isn’t going to blow on your face before you sit down.

Lighting, Computers

8. Remove half of the fluorescent bulbs in your office if you are light sensitive. Consider desk lamps for lighting.

9. Use a screen filter on your computer to minimize glare and reduce eye strain.

10. Use computer glasses (prescription strength are available through optometrists) to minimize glare and reduce eye strain.

11. Dim computer monitors and cell phone screens to minimize glare and reduce eye strain.

12. Take breaks from your computer and while reading anything.

13. Consider audio books to reduce eye strain.

14. Remember to blink. Put a Post-it note on your computer, or download an app to remind you.

15. Limit computer and electronic device use as much as possible.

Light Sensitivity

16. Wear wrap-around sunglasses. (I like Fitovers). I wear two pairs of regular sunglasses on bad days. Or sometimes I put the disposable glasses I get at the optometrist’s office inside my regular sunglasses for added protection from the bright sunlight.

17. Ask your ophthalmologist to approve extra dark tinted windows for your car if you are light sensitive.

Filaments

18. Wear bandage contact lenses when your eyes are burning or you have filaments. The lenses reduce pain when air hits the cornea. These lenses have been a lifesaver for me, especially on bad days. I get a prescription for Biotrue ONEday disposable lenses by Bausch & Lomb. They don’t come in Plano (no prescription), so I get the -0.25 prescription lens. You may need to work with your optometrist and try several brands to see what is most comfortable for you. Wear the bandage lenses only when you’re having filaments, or when the burning sensation is intense, because long-term contact lens use can also cause dryness.

Sleeping

19. Use nighttime gel at night in the corners of both eyes, or inside the lower lids. (I like Systane Nighttime Ointment). Be sure to reapply during the night if you wake up for any reason.

20. If you sleep with your eyes even partially open, wear an eye mask or moisture chamber goggles. The parts of the eyes that are exposed to air dry out while you’re sleeping and you wake up in pain, with burning eyes. A mask can help to keep your lids completely closed (but not always), and moisture chamber goggles keep the moisture in.

Clearing Debris

21. Flush your eyes with sterile saline several times a day. Flushing clears out any irritating particles. Sterile saline is safe and preservative-free, available OTC or with a prescription. Just don’t use it so much that you dry out your eyes and make things worse. Use an emergency eyewash station only short-term if sterile saline is not available.

Nutrition and Supplements

22. Take fish oil supplements to increase Omega-3 consumption. (I use the Thera Tears brand). It takes a while to see any improvement, but it does help.

23. Reduce sugar intake. It feeds inflammation

24. Reduce caffeine intake. It dehydrates you and alters meibum production.

25. Drink Lots of water! Stay hydrated.

Doctors

26. Find an ophthalmologist who specializes in Dry Eye, not one who just prescribes eye drops. (Ophthalmologists are MD’s who can diagnose and treat more complicated conditions and perform surgery if you need it). Find an optometrist who will work with you on glasses, or fit you for bandage, or wet, contact lenses.

27. It’s important to treat underlying causes of Dry Eye and any other systemic conditions to prevent further damage to your eyes. Find doctors who know your conditions and are willing to take the time to listen to what you’re going through.

Air Quality and Humidity

28. Use humidifiers in the bedroom and office to put moisture in the air. Many environments are dry, and offices keep the air dry because of copier paper curling. If possible, keep humidity levels around 40% . Mold can grow if there’s too much moisture in the air,

29. Use an air purifier in the bedroom to reduce dust and pet dander.

30. Try keeping pets out of the bedroom. I know this one is hard for some, but it helped me.

31. Avoid dusty and moldy places like basements, attics, and storage facilities.

Fumes and Smoke

32. Avoid smoke. The smoke from fires, fire pits, bonfires, cigarettes, and fireplaces can be very irritating. Check which way the wind is blowing if you’re going to watch fireworks.

33. Ask for help with housework so chemicals and irritants, and their fumes, don’t get in your eyes.

34. If hiring a maid isn’t an option, try wearing onion glasses (available at Bed Bath & Beyond or Williams Sonoma) whenever you clean or are around irritants. Even natural cleaning products, like white vinegar, can be irritating to the eyes.

OTC/At Home Treatments

35. Use warm and cold compresses — warm for MGD to open the glands and keep the meibum flowing, and cold to relieve pain.

36. Use cold compresses on the eyes as a last resort because they lower the temperature of the meibum and make it harder to flow.

37. Keep OTC drops and bandage lenses with you at all times.

38. Only use preservative free eye drops.

39. Use lid scrubs for crusts on your lids and lashes. (I like the Systane lid wipes which are individually packaged and great for travel).

Pain and Medications

40. Take Vicodin for extreme pain. It can dry out your eyes more, but gets you over the hump.

41. Review your medication list and avoid pain relievers, hormones, anti-depressants and all meds that cause dryness. Talk to your physician about substitutions.

42. Take Pilocarpine 3-4 times a day to increase tear production.

43. Ask for lots of gel in the eyes when having surgery to reduce further drying.

Life-Style

44. There will be some days when you’re just not able to drive. Always have a backup driver on deck for those unexpected bad days.

45. Wash your hands often. Dry Eye sufferers tend to touch their eyes frequently to clear away debris, instill drops, blot, or a host of other reasons. Hands need to be impeccably clean to avoid contamination or getting anything in the eye. Just washing with warm soap and water, and drying thoroughly, is usually enough to remove dirt and microorganisms that can cause infection. (OcuSoft makes a special hand soap for contact lens wearers that I like).

46. Surround yourself with positive people who will lift you up, and not tear you down, so you don’t spiral into depression. You need a strong support group!

47. Try to reduce stress and avoid stressful situations. If you have Dry Eye from an autoimmune disease it will always flare up when you are under stress.

48. Don’t wear eye makeup or try serum that boosts lashes. Makeup can flake and get into your eyes and glands, and cause more discomfort

49. Get plenty of rest.

50. Never give up!

Susie Brockman, Chronic Dry Eye Patient

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🔊 Listen

If you’re like many Dry Eye patients, you’re always on the lookout for new Dry Eye therapies, information about existing therapies, or wondering what might be on the horizon.

Here are our latest product updates. (View our advertising policy).

CyclASol®, Reduces Fluorescein Staining

According to its manufacturer, Novaliq GmbH, CyclASol, a preservative-free cyclosporine A solution, reduced corneal fluorescein staining in a phase 2 clinical trial for patients with moderate to severe Dry Eye.

Cyclosporine A is an antibiotic and the active ingredient in RESTASIS (a.k.a. IKERVIS). It’s good to hear about a preservative-free version, especially for those who might benefit from the drop, but would prefer to avoid long-term exposure to preservatives.

http://www.novaliq.com/2017/01/05/novaliq-announces-positive-topline-results-of-phase-2-clinical-trial-evaluating-cyclasol-in-adults-with-moderate-to-severe-dry-eye-disease/

Seciera™, Proprietary Cyclosporine A

Sun Pharma announced Phase 3 confirmatory clinical trial results for Seciera, another preservative-free cyclosporine A drop with a “patented, novel, proprietary nanomicellar formulation.”

http://www.sunpharma.com/media/press-releases

Klarity, Rehabilitates and Stabilizes

Imprimis announced exclusive rights to Klarity, a preservative-free, topical solution and gel containing chondroitin sulfate, for patients with Dry Eye. According to its press release, Klarity protects and rehabilitates the eye’s surface after surgery, wearing contact lenses, or in cases of moderate to severe Dry Eye. It treats edema and free radical formation associated with Dry Eye and “can serve as a cell membrane stabilizer.”

http://irdirect.net/prviewer/release/id/2426340

Cannabinoid-based Therapy (Yes, Cannabis)

Ora Inc. has been retained by AXIM Biotechnologies for product development and clinical trials on glaucoma and Dry Eye treatments using cannabinoid-based ingredients. From the sound of it, the therapy is likely focused on reducing pain or other discomfort, rather than treating any underlying cause of disease.

http://aximbiotech.com/wp-content/uploads/2017/05/AXIM_03212017_ORA-CSA-MEDIA_FINAL.pdf

Human Lubricin ECF843, Improves Dry Eye Signs

Novartis will in-license ECF843 (a human lubricin protein) worldwide (outside Europe). In a phase II study, with 28-days patients showed improved signs of Dry Eye. More testing is to be expected.

https://www.novartis.com/news/media-releases/novartis-strengthen-rd-pipeline-licensing-ecf843-ophthalmic-indications

TrueTear™ Intranasal Tear Neurostimulator

The FDA recently approved Allergan’s TrueTear hand-held tear stimulator. The device has two prongs that emit small pulses. Choose the strength level, place prongs in nostrils, and voilà, tears!

Doctors sometimes place Q-tips in nostrils to test reflexive tear production, a tear that is more caustic then normal tear film. So, could TrueTear exacerbate Dry Eye symptoms?

http://www.truetear.com/

Probing Restores Meibomian Glands

Although more studies are likely, and necessary, this one suggests meibomian glands can be restored, or regrown, with probing. That’s good news for anyone with obstructive meibomian gland dysfunction.

http://bjo.bmj.com/content/early/2017/06/06/bjophthalmol-2016-310097.full

P-321, Keeps Eyes Hydrated

Parion Sciences agreed to grant Shire “exclusive worldwide rights to develop and commercialize P-321. P-321 is “an investigational epithelial sodium channel (ENaC) inhibitor” for treating Dry Eye. P-321 may block tear absorption and keep the surface of the eye hydrated. Additional clinical studies are still required.

https://www.shire.com/en/newsroom/2017/may/o53zxn

Zerviate, for Allergies

Nicox received FDA approval for Zerviate, a topical eye drop containing the antihistamine cetirizine, for ocular itching associated with allergic conjunctivitis. Cetirizine is the active ingredient in Zyrtec. Allergic conjunctivitis can contribute to Dry Eye symptoms.

http://www.nicox.com/assets/files/ZERVIATE_FDA_Approval_20170531_EN.pdf

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🔊 Listen
Many years ago, before I learned I was a bad blinker, I attended a job-related rally being covered by the local news stations. When a reporter approached and asked to interview me, I happily agreed. That evening the interview aired on the local news channel. I was excited about being on TV, that is, until I saw myself. I was blinking a lot, a whole lot.

Still young and vain, I’d hoped anyone who was watching and knew me wouldn’t notice my crazy blinking. Beyond that, I didn’t give the excessive blinking too much thought, brushing it off as something having to do with my nerves. Maybe it was some kind of nervous tic, like when people wrinkle their noses or grind their teeth when they’re talking to someone.

I Was Always the One Ruining Photos

Eventually I noticed that in photographs I was always the one caught blinking, making me look like I’d had an adult beverage, or two, too many. If my eyes happened to be open, they always looked tired, making me feel self-conscious. I began avoiding cameras like the plague, unless I was wearing sunglasses or, if not those, my reading glasses.

By now you’re probably wondering why I’m going into so much detail about my bad blinking. It’s simple. Before being diagnosed with chronic Dry Eye, I took blinking for granted (except as noted above). Blinking to me was just a natural process, and while I blinked a lot, I really had no clue about the important role blinking plays in eye health.

Who Knew Anyone Could be a Bad Blinker?

Then, with the onset of Dry Eye, I would wake every day with a foreign body sensation in my eyes. It felt as if sand was imbedded in them. The feeling would cause me to blink like a maniac. My husband said my head bobbed with every blink. So with painful eyes, and a bobble head, I visited a Dry Eye specialist who sat me in front of a computer that tests blink rate. I found out I was a partial blinker, meaning when I blink my eyes don’t close completely. The condition even has a name: lagophthalmos. Who knew anyone could be a bad blinker?

It turns out the average person blinks 15 to 20 times per minute. That adds up to a lot of blinking throughout the day. With every blink, tear film in the eyes renews. Tear film consists of three layers: a mucus layer near the surface of the eye; a watery layer in the middle; and an oily layer on top that prevents the watery layer from evaporating. (Some research suggests that these layers aren’t completely separated).

My-Bow-Me-An Glands

Meibomian glands (pronounced my-bow-me-an) are tiny finger shaped glands in the eye lids. With every blink, they secrete the oil, known as meibum, through openings along the lid margin. At the same time, lacrimal glands — almond shaped glands beneath the outer corner of the eye brow — secrete the watery layer. The oily and watery layers spread across the ocular surface during the blink, lubricating the eyes. Tear film drains out through the tear ducts, carrying bacteria and other debris.

When the eyes need to, they automatically blink again, and the entire process repeats itself. A bad blinker, with a low blink rate or a partial blink, interrupts the delicate tear film cycle, reducing tear film production and leading to dryness.

Once I learned all of this, I understood how important it was for me to blink consciously, making sure I closed my eyes completely with each blink. I constantly struggle with this, but I’m determined to improve and stop being a bad blinker. You know how it is. You’re watching TV, talking the phone, or checking Facebook, and you catch yourself with that deer-in-the-headlights stare. Not good. Staring only makes things worse for a bad blinker.

Blinking Exercises

Blinking exercises can improve what you secrete and how you blink. I’ve tried them, but I find it hard to remember to do them. It’s something you might discuss with your doctor. He or she might recommend one or more of these exercises to improve blinking and reduce dryness.

While I’m still a partial, bad blinker who blinks too much, I make a conscious effort to blink fully throughout the day. Maybe one day I’ll even be able to say “cheese” in front of a camera without my sunglasses. So here’s to blinking, the right way!

Susan Howell

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🔊 Listen
When you first started treating Dry Eye symptoms, you may have started out using lubricating eye drops, most likely the less expensive ones with preservatives. For a while, maybe they helped. Maybe they still do. Or, maybe they don’t.

If you progressed beyond just lubricating drops, along the way you probably used some prescription medications to treat infections, inflammation, or allergies.

It’s possible you used something to clean your eyelids and lashes, or something to get rid of demodex mites.

Some of you had in-office procedures — tear duct cautery, meibomian gland probing, Lipiflow, gland expression, IPL, to name just a few.

Some even underwent surgeries.

What about supplements like omega-3 or lutein? Did you add those to your diet? Did you change it in other ways?

How about water, do you drink lots more now?

Some of you use lenses, like Scleral lenses or Dailies Total 1’s.

Warm compresses anyone? How many times a day and for how long?

Maybe you sleep with moisture chamber goggles at night and go out with wrap-around glasses during the day? Don’t’ worry, no one thinks you’re fooling around. Although some people might say you’re crazy. Have you heard, “It’s all in your head?”

It would be comical if it wasn’t so serious. Dead serious. And expensive. Did we mention PAINFUL?

Are You Treating Your Dry Eye or Someone Else’s?

Whenever we Dry Eye patients get together we like to talk about our symptoms and treatments. It goes something like this.

This is how I feel. How do you feel?

This is what helps my symptoms. What helps your symptoms?

We ask and we tell because we’re all desperate to feel better and get our lives off permanent hold. But there’s a risk, one that we should all be aware of.

Are you treating your Dry Eye or someone else’s?

What works for one person won’t necessarily work for another person, because all of our Dry Eye conditions are unique and special to each of us, just like our fingerprints.

Does knowing that make you feel any better?

We didn’t think so.

Consider a broken leg. If you show up at the ER with a broken leg, it’s quite likely the doctor will order an X-ray before setting the bone. Why? Because your bone and the break are unique. The doctor can’t treat yours the same way he treated the broken leg that came in the ER two hours ago.

If later, you run into someone who has a broken leg, you’ll probably compare notes. This is how I broke my leg, what the doctor did, and what I’m doing now. You might even exchange tips on how to scratch those hard to reach spots, how to keep your cast dry, or how to manage pain.

Each Dry Eye Patient is Unique

But you probably won’t rip apart your cast and try to reset your leg yourself. For one it would be hard to do (not to mention foolhardy), but you also recognize that your broken leg is unique to you

So just be mindful, when you’re chatting or talking with someone about your Dry Eye symptoms and set of conditions, that you don’t start treating something you don’t have. It’s a good idea to check with your doctor before you try anything new.

And yes, ask questions. Lots of them. The more you know the better, because your Dry Eye condition is unique to you and needs to be treated that way.

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